Patricia Oluchukwu Okonkwo, Blessing Edagha, Raphael John Ogbe

Department of Chemical Pathology, Federal College of Veterinary and Medical Laboratory Technology, N.V.R.I. Vom, Plateau State, Nigeria

Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, Makurdi, Benue State, Nigeria

Key words: Alcohol, liver, enzymes, hepatotoxicity.


This study was conducted to investigate the effect of alcohol consumption on the liver of apparently healthy human subjects resident in Vom and its environs. Blood samples were collected from 120 subjects and serum level of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline Phosphatase (ALP) were estimated by IFCC kinetic method using available commercial Reagent Kit (DIALAB Scientific Laboratories, Austria) and colorimetric end point method. All the enzymes, ALT, AST and ALP assayed were significantly higher (p<0.05) in alcoholics than non-alcoholics. The frequency distribution shows that greater percentage of alcoholics have above normal levels of all liver enzymes assayed while greater percentage of non-alcoholics have normal levels of the liver enzymes, the age group (41- 50 years) has greatest percentage of high levels of the enzymes and greater percentage of men have high levels of the enzymes than women. Therefore, the study suggests that excessive consumption of alcohol predisposes humans to the risk of developing alcoholic liver disease and men are at greater risk than women in Vom and its environs.

Get the original articles in Source: Volume 2, Number 4, April 2012

Published By: International Journal of Biosciences (IJB)

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